Oste­oFit

“3D-​Bioprinted Bone Tis­sue inside High Res­o­lu­tion 3D-​Printed Molds for the Effec­tive Treat­ment of Bone Tis­sue Deformations”

The first step in the imple­men­ta­tion of Oste­oFit is the design of the printed matrix of the model for the cre­ation of the com­pos­ite implant. A clin­i­cal file of 3D imag­ing method will be selected and cre­ated the three-​dimensional model with the design of the fea­tures of the com­pos­ite implant, such as nutri­ent flow chan­nels and stress trans­fer fea­tures. In this com­pu­ta­tional model, there will be stud­ied the nutri­ent flow with com­puter fluid dynam­ics (CFD) and the sim­u­la­tion of nor­mal stresses with finite ele­ments (FEM) based on mechan­i­cal prop­er­ties described in the tech­ni­cal char­ac­ter­is­tics of bio­com­pat­i­ble resins to be used. This model will be printed with bio­ma­te­ri­als to cre­ate a high-​resolution mold and will be eval­u­ated for the actual flow field and stresses, as well as the in vitro bio­com­pat­i­bil­ity. Finally, there will be pub­li­ca­tions of results of work in con­fer­ences. The biore­ac­tor has the key role in the mechan­i­cal and bio­log­i­cal mat­u­ra­tion com­pos­ite implant.

The Role of BL NanoBiomed:

BL NanoBio­med will opti­mize the ratio of the bioink of the 3D bio­printed bone tis­sue, cells, micro-​and nano-​structured par­ti­cles and addi­tional com­po­nents. This cell-​laden paste will be bio­printed within the 3D printed mold to cre­ate the com­pos­ite implant.