Nanomed for implants

Prod­ucts


BL Nanobio­med offers inte­grated and cus­tomized solu­tions for the devel­op­ment of the novel nano­ma­te­ri­als (drug deliv­ery nanosys­tems, nanopar­ti­cles, scaf­folds and nanocoat­ings) processes, equip­ment and qual­ity con­trol tools that can be effi­ciently com­bined for improved implants performance.

Novel Drug Deliv­ery Nanosystems

  • for the Con­stant release of anti-​inflammatory, anti-​restenotic, anti-​thrombotic Drugs to over­come Stent com­pli­ca­tions and pro­mote tis­sue regeneration
  • that guar­an­tee a Sus­tained Release of anti-​inflammatory drugs or antibi­otics from ortho­pe­dic implants & sur­gi­cal tools
  • for the sus­tained Intraoc­u­lar release of anti-​inflammatory drugs after cataract surgery
  • for con­trolled anti-​inflammatory drugs release with sooth­ing and anti-​aging prop­er­ties for skin applications
  • to release anti-​oxidant agents to treat ath­er­o­scle­ro­sis and other chronic high oxida­tive stress– related dis­eases (neu­rode­gen­er­a­tive, can­cer, arthri­tis, etc.)
  • with enhanced anti-​microbial properties

Pro­to­types


Nanoporous mul­ti­func­tional mate­ri­als for drug delivery

What can we achieve with the engi­neered Drug Elut­ing Nanosystems?

  • Con­trol­lable, tar­geted and sus­tain­able drug release at the dis­eased site for opti­mized effectiveness
  • Customer-​made design to meet the require­ments for each med­ical application
  • Deliv­ery of dif­fer­ent drugs even insol­u­ble ones
  • Min­i­mized tox­i­c­ity due to their full biodegrad­abil­ity and no per­ma­nent pres­ence in the human body
  • Appli­ca­tion to a wide range of implants and bio­med­ical devices (e.g. car­dio­vas­cu­lar, ortho­pe­dic, sur­gi­cal, neu­ro­log­i­cal implants, lens, patches, etc)

…Such sys­tems will form the basic com­po­nents of highly added value med­ical prod­ucts designed to diag­nose and treat human diseases.

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Ther­a­nos­tic Biodegrad­able Nanoparticles


…for Tar­geted Diag­nos­tic and Ther­a­peu­tic Activities

theranostic 01

Diverse Biodegrad­able Nanopar­ti­cles loaded with drugs for treat­ment of Ath­er­o­scle­ro­sis and other chronic diseases.

Scaf­folds for Tis­sue Regeneration
  • Elec­tro­spin­ning Sys­tem Deposition
  • Bio­func­tion­al­iza­tion
  • Physic­o­chem­i­cal and Bio­log­i­cal Characterization
  • In vitro regen­er­a­tion of bone, car­ti­lage, skin, car­diac tissues

scaffolds 01

(a) SEM and (b) AFM images of Elec­tro­spun
nanoscaf­folds for tis­sue regeneration

scaffolds 02

Scaf­folds for Drug Deliv­ery and Tis­sue Regeneration


…for Sus­tained and Con­trol­lable Drug Release and Tis­sue Regeneration

scaffolds 03

Drug Deliv­ery Nanoplatforms:

  • Con­trol­lable and sus­tained release of drugs
  • Encap­su­la­tion of mul­ti­ple nanocarriers
  • Con­trol­lable biodegra­da­tion ratio through the body
  • Con­stant release of anti-​inflammatory, anti-​restenotic, anti-​thrombotic Drugs to over­come Stent complications
  • Sus­tained Release of anti-​inflammatory drugs or antibiotics
  • Tar­geted Drug Deliv­ery at the dis­eased site

Biodegrad­able Scaf­folds onto Implants

Nanofi­brous nanoplat­forms to be used coat­ings onto implants via Elec­tro­spin­ning Deposition

implants 01

implants 02

Car­dio­vas­cu­lar Implants (stents, car­diac valves)

  • Release of anti-​inflammatory, anti-​oxidant and antiplatelet drugs
  • Pro­mote implant endothelialization

Ortho­pe­dic Implants

  • Release of anti-​inflammatory and antibi­otic drugs
  • Pro­mote implant inte­gra­tion with sur­round­ing tissues
  • Inhi­bi­tion of implant infection

Nanomed­i­cine for Antimi­cro­bial Surfaces
  • Bac­te­ria and micro-​organisms con­cern­ing a major issue in clin­i­cal treat­ment due to the soft and easy growth and repro­duc­tion activity
  • Nan­otech­nol­ogy can undergo this prob­lem via nanos­truc­tures with antimi­cro­bial activity

antimicrobial 01

Poly­meric nanocomposites

  • Super hydropho­bic
  • Super killing properties
  • Nano pil­lars
  • Scaf­folds
  • Antimi­cro­bial surface
antimicrobial 02
antimicrobial 03
  • Sil­ver and ZnO nanopar­ti­cles with unique antimi­cro­bial properties
  • Elec­tro­spray­ing of NPs onto sur­faces → enhance of antimi­cro­bial & antibac­te­r­ial behavior

Organic Biosen­sors for Heart Attack Diagnosis


Devel­op­ment of Print­able Biosensors

  • Accu­rate & Early Detec­tion of Myocar­dial Infraction
  • Use of novel Biomarkers
  • Inte­gra­tion of NanoMed Tech­nolo­gies with Organic Electronics
  • Spe­cific Con­fig­u­ra­tion and Bio­func­tion­al­iza­tion of the Biosensor
  • Highly Speci­ficity, Lin­ear­ity in Sig­nal response
  • Low cost, Mass Production

biosensors 01

In col­lab­o­ra­tion with OE-​Technologies P.C.

Nanopar­ti­cles for Heart Attack Diagnosis


Inor­ganic NPs are valu­able tools for a wide range of Bio­med­ical Applications:

  • Bio-​detection
  • Bio imag­ing
  • Drug and Gene Transfer
  • Dis­ease diagnosis
  • Tar­geted Chemotherapy
Con­trol AuNPs (AFM Images) Bio­func­tion­al­ized AuNPs (AFM Images)
nps heartattack

3D Bio­print­ing


Three dimen­sional (3D) Bio­print­ing is the uti­liza­tion of 3D Print­ing that com­bines cells, growth fac­tors, and bio­ma­te­ri­als to fab­ri­cate bio­med­ical parts that max­i­mally imi­tate nat­ural tis­sue characteristics.

  • Layer-​by-​layer depo­si­tion of mate­ri­als (Bioinks)
  • Tissue-​like struc­tures for med­ical and tis­sue engi­neer­ing applications.
  • Broad range of biomaterials

3D Bio­print­ing has begun to incor­po­rate the print­ing of scaf­folds that can be used to regen­er­ate osteo­chon­dral defects, car­ti­lage, lig­a­ments and other tissues.

In col­lab­o­ra­tion with OE-​Technologies P.C.

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