Project ID: Τ2ΕΔΚ-03546
“3D-Bioprinted Bone Tissue inside High Resolution 3D-Printed Molds for the Effective Treatment of Bone Tissue Deformations”
The first step in the implementation of OsteoFit is the design of the printed matrix of the model for the creation of the composite implant. A clinical file of 3D imaging method will be selected and created the three-dimensional model with the design of the features of the composite implant, such as nutrient flow channels and stress transfer features. In this computational model, there will be studied the nutrient flow with computer fluid dynamics (CFD) and the simulation of normal stresses with finite elements (FEM) based on mechanical properties described in the technical characteristics of biocompatible resins to be used. This model will be printed with biomaterials to create a high-resolution mold and will be evaluated for the actual flow field and stresses, as well as the in vitro biocompatibility. Finally, there will be publications of results of work in conferences. The bioreactor has the key role in the mechanical and biological maturation composite implant.
The Role of BL NanoBiomed:
BL NanoBiomed will optimize the ratio of the bioink of the 3D bioprinted bone tissue, cells, micro-and nano-structured particles and additional components. This cell-laden paste will be bioprinted within the 3D printed mold to create the composite implant.